“Social Processes” is a major behavioral domain for study in the RDoC Matrix (https://www.nimh.nih.gov/research-priorities/rdoc/constructs/rdoc-matrix.shtml). Alterations in social behaviors are features of communication disorders, certain anxiety disorders, ASD, and SZ. Human genetic studies with patients displaying social dysfunction have identified various polymorphisms associated with these abnormalities. Similarly, a number of different mouse inbred strains as well as genetic models have identified phenotypes that display aberrant social behaviors. However, with few exceptions the conventional KO mice approach has failed to provide clear mechanistic insights into disorders. Current hypotheses posit that certain genetic mutations may impair the functioning of neural circuits that subserve social behavior.